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- Supplemental or physiologic doses of testosterone have observed expanded use in medical follow lately.
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Patients also may be taking concomitant stimulants, such as ephedra, which may confound data and the potential for opposed events. It is probably going that the frequency of cardiac occasions is underreported within the medical literature. Moreover, testosterone has been used within the therapy of lowered muscle mass and bone density in addition to anemia. The position testosterone may play in the development of cardiovascular disease has increasingly turn into the subject of present curiosity . Supraphysiologic doses of anabolic-androgenic steroids , which embrace more than 30 pure and artificial derivatives of testosterone, might cause a large spectrum of medical sequalae. Supplemental or physiologic doses of testosterone have observed expanded use in medical apply recently. Other common potential opposed results embrace infertility, hepatotoxicity, psychological abnormalities, and gynecomastia .
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However, testosterone in physiologic doses might even be useful in sufferers with angina , have greater ischemic thresholds and improved quality of life . Short-term intracoronary administration of testosterone induces coronary artery dilation and will increase coronary blood circulate in men with established coronary artery illness . Therefore, an interplay of endogenous factors of the patient’s risk profile in addition to the testosterone dosing may be issues of whether opposed events happen. Erythrocytosis has been reported as a potential effect of testosterone, which could be helpful in patients with anemia.
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We report a case of an acute ST-segment elevation myocardial infarction in a patient with conventional cardiac danger factors using supraphysiologic doses of supplemental, intramuscular testosterone. In addition, this affected person additionally had polycythemia, doubtless secondary to high-dose testosterone. The patient underwent profitable percutaneous intervention of the right coronary artery. Physicians and patients should pay attention to the clinical penalties of anabolic steroid abuse. Development of an atheromatous plaque perpetuates endothelial dysfunction and promotes platelet aggregation and intracoronary thrombus formation (Ajayi et al 1995; Nieminen et al 1996). Moreover, a part of endothelial dysfunction has been proposed, which can contribute to irregular vessel reactivity.
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